Advanced Lipid Management

Q: Why not just take a statin and check LDL once a year?

For many patients, that's enough — and we will tell you when it is. But two scenarios benefit from a more focused approach: (1) Patients whose LDL number looks fine on paper but whose actual atherogenic-particle burden (apoB) is elevated, which standard testing misses in roughly a third of cases. (2) Patients who are at high or very-high risk where the LDL target is below 70 or even below 55 mg/dL, and getting there requires combination therapy or newer agents. Both groups are routinely undertreated when they only see primary care.

Q: What is apoB and why does it matter more than LDL?

Every atherogenic lipoprotein particle in your blood — LDL, VLDL, IDL, Lp(a), and the remnants — carries exactly one apolipoprotein B molecule. Measuring apoB directly counts the number of those particles. LDL cholesterol measures the cholesterol content of one of those particle classes, which is only an estimate. When LDL and apoB diverge (about 30% of patients), apoB is the more accurate predictor of events, and it is what we treat to target in modern lipid management.

Q: What about Lp(a) — should I get it tested?

Yes, once. About 20% of the population has an elevated Lp(a) — a genetically determined, independent driver of heart-attack and aortic-valve risk. Knowing your Lp(a) status doesn't change the test itself (it's a one-time blood draw), but it changes how aggressively we treat everything else: the higher your Lp(a), the more we want your apoB driven down. New Lp(a)-lowering therapies are in late-stage trials; for now, the action item is intensified treatment of every other lipid lever.

Q: What if I cannot tolerate a statin?

True statin intolerance is uncommon (a few percent of patients) but real, and it's also widely overcalled — many patients who think they have statin intolerance turn out to do fine on a different statin, a different dose, or every-other-day dosing. A structured rechallenge protocol confirms or rules out true intolerance. When intolerance is real, modern alternatives — ezetimibe, bempedoic acid, PCSK9 inhibitors, and inclisiran — can achieve target apoB without a statin at all.

Q: Can a virtual cardiologist manage my lipids?

Yes — lipid management is one of the best fits for a virtual cardiology relationship. The visits are largely about reviewing labs and adjusting therapy, both of which work cleanly over video. Labs are drawn at a lab close to your home, results return electronically, and dose adjustments and prescriptions are sent the same day. Most patients can be brought to lipid target in two to four virtual visits over a few months.

Advanced Lipid Management

Lipid management is one of the highest-leverage levers in cardiology: a 50% reduction in apoB-containing particles, sustained over years, is what underpins most of the modern reduction in cardiovascular events. Standard care will get many patients part of the way there. This program is for the patients who want the rest of it — measured precisely, treated to target, and reviewed by a cardiologist who keeps up with the field.

Reviewed by Rahul C. Deo, MD, PhD · Last updated May 20, 2026

What "advanced" lipid management actually means

Most adults have had a basic lipid panel at some point — total cholesterol, LDL, HDL, triglycerides. That panel is fine as a screening test. It is not enough for clinical decisions in the patients who matter most: high-risk primary prevention, secondary prevention after an event, familial hypercholesterolemia, and anyone with discordant cholesterol-and-particle numbers.

Advanced lipid management adds the tests that resolve those decisions, and a treatment approach that uses the full modern therapeutic toolkit — not just whichever statin happens to be cheapest.

The diagnostic side — what we test

Apolipoprotein B (apoB)

The direct count of atherogenic particles in your blood. The target depends on your overall risk: roughly <90 mg/dL for primary prevention, <80 for elevated-risk patients, and <65–70 for secondary prevention.

Lipoprotein(a) — Lp(a)

One-time blood test that identifies whether you carry an elevated Lp(a). If yes, the rest of the plan is intensified accordingly. If no, that is also useful — you've ruled out a significant genetic risk factor.

Lipoprotein-particle number / size (NMR or ion-mobility)

When apoB and LDL tell different stories, lipoprotein-particle testing characterizes the discordance. Most often used for patients with metabolic syndrome, insulin resistance, or significantly elevated triglycerides.

Genetic testing for familial hypercholesterolemia (FH)

For patients with personal or family history suggesting FH — very high LDL from a young age, premature heart disease in first-degree relatives. A confirmed FH diagnosis changes both treatment intensity and family screening.

The therapeutic side — what we treat with

Statins, used correctly

Still the foundation. The right approach is the right statin and dose for your target, with follow-up labs to confirm we've hit the number. Many patients are on a low-dose statin that came from a starter prescription years ago and was never titrated to target.

Ezetimibe

Cheap, well-tolerated, additive to statin therapy with a known cardiovascular outcomes benefit. Underused in routine practice. Often the first add-on when statin alone doesn't reach apoB target.

PCSK9 inhibitors (evolocumab, alirocumab)

Injectable monoclonal antibodies that lower LDL and apoB by an additional 50–60% on top of statin therapy. Outcome trials show clear cardiovascular benefit. Coverage is broader than most patients realize; we handle the prior authorization.

Inclisiran

Twice-yearly injectable siRNA that silences hepatic PCSK9 production. Equivalent LDL lowering to the antibodies, with a dramatically simpler dosing schedule.

Bempedoic acid

Oral, statin-independent, useful in statin-intolerant patients and as an add-on for patients who can't reach target on statin alone.

Icosapent ethyl, for patients with elevated triglycerides on statin

Evidence-based add-on with a cardiovascular outcomes benefit in high-risk patients whose triglycerides remain elevated despite statin therapy.

How the program runs

First visit (30 min). Review your history, family history, prior labs, current medications, lifestyle, and goals. Order the advanced lipid panel + any other tests indicated.
Labs drawn near home. Quest, LabCorp, or a local lab — wherever is most convenient. Results arrive electronically.
Follow-up visit (15–30 min). Walk through the results together. Build the treatment plan: target, regimen, whether add-on therapy is needed.
Titration visits as needed. Labs at 8–12 weeks after each change to confirm response. Most patients reach target in two to four titration cycles.
Ongoing. Annual labs and one follow-up visit per year is typical for stable patients.

The bottom line

Lipid management is the single most heavily evidence-based intervention in adult cardiology. Done with the full modern toolkit, targeted to apoB, and tuned to the individual's true risk, it is also one of the highest-leverage things you can do for your long-term cardiovascular outcomes. This program is designed to bring that level of care within reach of a virtual visit.

Common questions

Why not just take a statin and check LDL once a year?

For many patients, that's enough — and we will tell you when it is. But two scenarios benefit from a more focused approach: (1) Patients whose LDL number looks fine on paper but whose actual atherogenic-particle burden (apoB) is elevated, which standard testing misses in roughly a third of cases. (2) Patients who are at high or very-high risk where the LDL target is below 70 or even below 55 mg/dL, and getting there requires combination therapy or newer agents. Both groups are routinely undertreated when they only see primary care.

What is apoB and why does it matter more than LDL?